B. Benzene chloro ketone. , Occupational exposure to benzalkonium chloride has been linked to the development of asthma. IUPAC Standard InChIKey: KCXMKQUNVWSEMD-UHFFFAOYSA-N; CAS Registry Number: 100-44-7; Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d … This table shows how each list refers to the substance. 0.1% is the maximum concentration of benzalkonium chloride that does not produce primary irritation on intact skin or act as a sensitizer. The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. , Benzalkonium chloride poisoning of domestic pets has been recognised as a result of direct contact with surfaces cleaned with disinfectants using benzalkonium chloride as an active ingredient. EPA Registry Name: Benzoyl chloride. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation).  Formulation can also help minimise deactivation of benzalkonium solutions in the presence of organic and inorganic contamination. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). In a 1998 study using the FDA protocol, a non-alcohol sanitizer with benzalkonium chloride as the active ingredient met the FDA performance standards, while Purell, a popular alcohol-based sanitizer, did not. Dissolution in water is slow. Benzalkonium chloride also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient, but at the risk of causing damage to the surface of the eye.. Welcome to the ECHA website. , Avoiding the use of benzalkonium chloride solutions while contact lenses are in place is discussed in the literature.. 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Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Registrants / Suppliers - Ceased manufacture, Registration numbers - Ceased manufacture, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. Benzoyl chloride . ", Benzalkonium chloride is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. , Many mass-marketed inhaler and nasal spray formulations contain benzalkonium chloride as a preservative, despite substantial evidence that it can adversely affect ciliary motion, mucociliary clearance, nasal mucosal histology, human neutrophil function, and leukocyte response to local inflammation. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. to prevent increases in viscosity or gel formation under low temperature conditions. Ingredients are categorized as Category III when "available data are insufficient to classify as safe and effective, and further testing is required”. Aqueous solutions should be neutral to slightly alkaline. This site is not fully supported in Internet Explorer 7 (and earlier versions). Information on Registered Substances comes from registration dossiers which have been assigned a registration number. List A consists of the 194 … Benzyl chloride Names Preferred IUPAC name (Chloromethyl)benzene. While the majority of cases were caused by confusion about the contents of containers, one case cites incorrect pharmacy dilution of benzalkonium chloride as the cause of poisoning of two infants. The mechanism of bactericidal/microbicidal action is thought to be due to disruption of intermolecular interactions. Since stearalkonium chloride is a type of BAC, the biodegradation process should happen in the same manner.
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